top of page
8-in-1 Bioserum

8-in-1 Bioserum


The 8-in-1 BioSerum is DefenAge's iconic bestseller. The remarkably smart formula seems to understand your skin’s needs better than your own DNA. Designed to activate, orchestrate and energize, this biologically-advanced anti aging cream-like serum concentrate provides an unprecedented concentration of defensin molecules contained in the Age-Repair Defensin® Complex. Dermatologists and aesthetic professionals name defensins as a perfect retinol alternative and the 8-in-1 BioSerum as a retinol serum replacement. The best part? Results are equal to 8 separate serums. Apply with the 24/7 Barrier Balance Cream to create smoother, younger looking skin. Patent-pending technology. Get the best skin ever today!

Expert opinions ►


  • •  Rejuvenates smoothness. Improves overall visible skin health and quality.
  • •  Minimizes the look of fine lines, wrinkles, pores, and skin pigmentation and discolorations.
  • •  Promotes radiance and revives the skin’s natural moisture for an ultimate glow.
  • •  Brightens the overall skin tone and clarity and enhances skin luminosity.
  • •  Renews the feeling of skin firmness, elasticity, and texture.
  • •  Helps improve the appearance of skin redness.
  • •  Promotes the skin barrier and immunity.


Why it’s different

  • •  Advanced targeted cosmetic treatment with an established and validated science. A unique mechanism of action.
  • •  Contains 5 times more defensin-molecules than any other formulas.
  • •  Light-weight application; “you don't feel it when you're wearing it”.
  • •  Effective and safe for the entire face, including the delicate skin around the eyes and lips, and the neck and décolleté. High-performing on the crepey thin skin on the neck and arms.
  • •  Fast acting anti-aging – first results are seen within a few weeks.
  • •  Perfect as a daily skincare product for both men and women.
  • •  Effective for both early and late stages of skin aging, including people above 70.
  • •  Non-irritating and gentle on sensitive skin overall, and over retinols.
  • •  Tolerated by all skin types. Good for rosacea and melasma patients, can be combined with other treatments for rosacea patients.
  • •  Highly effective for pre- and post- aesthetic procedures to achieve the optimal outcomes, including microneedling and fractional and resurfacing/ablative laser treatments. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.  
  • •  Effective to prep the skin and enhance filler results, recommended to use 4-6 weeks before a filler procedure.
  • •  DefenAge's most “likable” product with the most impressive consumer feedback.
  • •  Mega size, 1.5 fl oz, is now available.


Made in the U.S.A.

  • How to Use

    STEP THREE | 8-in-1 BioSerum 

    Daily: AM | PM

    Place 1 pump of 8-in-1 BioSerum (bio serum) onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.

    Suitable for all skin types.





    For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

  • Clinical Studies

    The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 7 clinical studies.



    The 8-in-1 BioSerum | Concept Anti Aging Cream was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.

    Additional opthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.

    The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.

    All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.

    We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile. 

  • Ingredients

    Age-Repair Defensins® | 5X  | DefenAge's Exclusive

    promotes new skin • anti-aging on a global scale • retinol alternative

    Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


    hydration • firmness & elasticity • brightening

    Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

    Hyaluronic Acid | Low Molecular Weight

    • hydration •

    Promotes hydration and improves texture for remarkably smooth and even skin.

    Sea Whip

    • skin calming & soothing •

    Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

    Fine Blends of Natural Antioxidants, Enzymes

    and Hydrating Technologies

    antioxidants • hydration • soothing

    Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


    The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excused from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.



    The bottle, box and package components are fully recyclable, please recycle.

    We do not test products on animals.


    8-in-1 BioSerum | Concept Anti Aging Cream

    Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Sea Whip Extract, Ergothioneine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Offinalis (Rosemary) Leaf Extract, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Albumin, L-Alanyl-L-Glutamine, Caprylic/Capric Triglyceride, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride.
    Fragrance free.

    This product does not contain retinol and should not be considered as a retinol serum.

bottom of page