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Clinical Power Trio

Clinical Power Trio


Clinical Power Trio+ is a PLUS-edition of our best-selling Clinical Power Trio; we upgraded it with the MEGA size 8-in-1 BioSerum.


CLINICAL POWER TRIO is DefenAge's signature, clinical-study tested, dermatologist recommended skin care treatment. We recommend starting DefenAge with the Clinical Power Trio:

  • •  Corrects visible signs of skin exhaustion, damage and aging on a global scale.
  • •  Defensin-loaded, DefenAge's core skin care regimen.
  • •  Efficacy proven based on comprehensive clinical studies.
  • •  Initial results appear in the first week of use. Full range of results - in 6 weeks.


This skin care is winner of the Aesthetic Award 2018, presented by Dermatology Times and The Aesthetic Channel, and is voted as the Nonsurgical Innovator of the year for The Aesthetic Awards 2019.

  • How to Use

    STEP TWO | 24/7 Barrier Balance Cream

    Daily: AM | PM

    Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
    Suitable for all skin types.




    STEP THREE | 8-in-1 BioSerum

    Daily: AM | PM

    Apply after 24/7 Barrier Balance Cream.

    30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
    Suitable for all skin types.




    1-2 Xs A WEEK | 2-Minute Reveal Masque

    Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream).
    Not recommended for acne, extremely sensitive or abraded skin.




    For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

  • Clinical Studies

    We are rigorously testing all our products for efficacy and safety. The Clinical Power Trio, its individual products and our signature ingredient Age-Repair Defensins, has been tested in 11 clinical studies by today. All products have been tested by Board Certified Dermatologists, and the 8-in-1 BioSerum, which is recommended to be applied on the areas around the eyes, was also tested by a Board Certified Ophthalmologist. All clinical studies returned outstanding safety and efficacy profiles; the data is published in peer-review clinical journals and presented on dermatologist and aesthetic medical conferences.


    The largest multi-center, placebo-controlled clinical study, which tested the Clinical Power Trio, underwent a review of independent Institutional Review Board and is published in the Journal of Drugs in Dermatology. The full text of the article and study results are available on the journal’s website. Based on the results of this study, dermatologists recommend defensins as an safe and efficient alternative to the cosmetic retinol. The study also proved the performance of Clinical Power Trio as an universal anti-aging skin care that addresses visible signs of skin aging on a global scale. Please visit Our Story page for before and after images and details about the multi-center study.



    • Taub A, Bucay V, Keller G, Williams J, Mehregan D. Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation. J Drugs Dermatol. 2018 Apr 1;17(4):426-441. PMID: 29601620.
    • Duncan DI. Microneedling with Biologicals: Advantages and Limitations. Facial Plast Surg Clin North Am. 2018 Nov;26(4):447-454. PMID: 30213426.
    • Taub AF, Pham K. Stem Cells in Dermatology and Anti-aging Care of the Skin. Facial Plast Surg Clin North Am. 2018 Nov;26(4):425-437. PMID: 30213424.
    • Keller G. Topically Applied Defensins for Comprehensive Improvement of Aging Skin. The American Academy of Facial Plastic and Reconstructive Surgery/COSM – Book of Abstarcts. 2016 A021.
    • Multi-Center, Double-Blind Clinical Study Validates DefenAge® As A Best-In-Class Anti-Aging Solution, Naturally Turning Back The Clock. Business Wire. 2018 Apr 03. Press Release.
    •  The Aesthetic Awards Introduces Peer Voting At Ninth Annual Ceremony. 2019 Sep 17. The Aesthetic Guide.
    •  The Aesthetic Show Annual Awards Ceremony Honors Aesthetic Innovators And Influencers. 2018 Sep 19. The Aesthetic Guide.
  • Ingredients

    Age-Repair Defensins® | DefenAge's Exclusive

    promotes new skin • anti-aging on a global scale

    Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


    hydration • firmness & elasticity • brightening

    Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

    Hyaluronic Acid

    Liposome Encapsulated (Cream) | Low Molecular Weight (Serum)

    • hydration •

    Promotes hydration and improves texture for remarkably smooth and even skin.

    Sea Whip

    • skin calming & soothing •

    Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

    Fine Blends of Natural Antioxidants, Enzymes

    and Hydrating Technologies

    antioxidants • hydration • soothing

    Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


    We have carefully formulated our products to exclude multiple harmful and questionable ingredients. In addition to DefenAge’s standard list of the excluded ingredients, products in this kit do not contain fragrance. DefenAge’s standard list of the excluded ingredients is shown on our Clean Beauty page.


    The tubes and box are fully recyclable, please recycle.

    Not tested on animals.

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